Expertise & Services

Expertise

Our expert team of scientists and technicians work in a state-of-the-art facility and balance work in research and development, which integrates seamlessly with the PC-TRiADD microarray facility, functional genomics and pathology service, as well as the clinical trials unit, to realize a comprehensive and focused translational research centre.

Services

  • Drug target identification and characterization
  • Computational drug discovery (virtual screening, combinatorial library construction, structure-activity modeling)
  • Computer-aided hit-to-lead optimization (ADME and Toxicity prediction, bioavailability and selectivity optimization)
  • Rapid and comprehensive evaluation of novel small molecules and biologics in preclinical model systems including:
    • Cytotoxicity assays
    • Clonogenic assays
    • Biomarker assays (established or novel)
    • Drug-target and off-target interaction assays
    • Drug-drug interactions
    • In Vitro and In Vivo tumour cell lines
    • GC and LC-MS assays for a variety of chemistries in biological matrices for GLP studies
  • Biomarker assay development
  • Single agent studies and combination studies
  • Pharmacodynamic and biomarker analysis of novel drugs in human clinical trials

The Living Tumor Laboratory

The Living Tumor Lab is a unique and valuable resource, which grows a wide variety of patient-derived cancer tissues, including both low and high-grade solid cancers.

This work enables researchers to readily study human cancer tissue in vivo and develop a variety of transplantable tumour tissue lines that can be used as models for studying cancer growth/progression/metastasis and drug sensitivity.

Visit the Living Tumor Laboratory website

News