The Vancouver Prostate Centre has a tumour bank that contains well over 2000 prostate cancer specimens (both fresh frozen and paraffin embedded). This tumour bank has an integrated database that is overseen by a full-time coordinator, along with a full-time research pathologist and staff.
The Vancouver Prostate Centre’s collection includes the world’s largest repository of the following:
- pre- and post-treated prostate cancers
- tumours stratified from low to high risk (matched primary and metastatic tumours)
- treatment resistant cancers fully annotated for previous therapies, responses, stage, and prognostic indicators, biomarkers etc.
An established bank of more than 700 human radical prostatectomy specimens stored at -156 degrees centigrade and in paraffin blocks
More than 1,000 archived prostatectomy specimens from patients with no prior hormone therapy or after variable periods of pre-treatment with one, three, or eight months of neo-adjuvant hormone therapy prior to surgery.
The VPC has also constructed the following:
- Tissue microarrays (TMAs) from post-treated cancer specimens that are useful for high throughput validation of transcriptional profiles.
- TMAs spotted with control normal prostate tissue together with more than 400 individual samples from benign, PIN, and Gleason grades of 3, 4, and 5 all linked to clinical correlative data and PSA recurrence rate status.
- A unique post-hormone therapy treated TMA consisting of a total of 336 cores from 112 patients treated with no hormone therapy (21), 3-6 (49), and more than 8 (28) months of neo-adjuvant hormone therapy prior to radical prostatectomy, and 14 patients with metastatic castrate resistant prostate cancer.
- TMAs from patients entered into the Canadian Uro-Oncology Group randomized comparative study of 3 vs 8 months of neo-adjuvant hormone therapy, as well as from a multicentre Phase II trial of 70 patients treated with neo-adjuvant hormone plus docetaxel, all with annotated clinical and pathological correlates.
- TMA of 14 metastatic lymph node lesions paired with biopsies from the primary lesion. Approximately half of these lesions have been pre-treated with androgen ablation therapy, and all have clinical correlative and follow up data.
The Vancouver Prostate Centre has been collecting human prostate tissue from patients undergoing radical prostatectomy for well over 15 years. The process of collecting and bio-banking these specimens has been undertaken with an institutionally approved consent form and each individual specimen has been consented for research purposes within the institution. VPC implements high ethical standards to protect patient’s confidentiality in this process.