Expertise & Services

Expertise

The Laboratory for Advanced Genome Analysis (LAGA) specializes in the acquisition, processing, statistical analysis, integration, and visualization of high-density sequencing and microarray data. Our highly trained technicians interpret complex data and offer important recommendations for the best possible use of genomics and transcriptomics technology. LAGA prides itself on providing clients with solutions that are rapid, economical and tailored to their needs.

LAGA has unique capabilities in the following areas:

  • Translational genomics, where genomics, computer science, and clinical science converge in diagnostics and therapeutics
  • Combined use of microarray and sequencing technologies
  • Advanced bioinformatics and data visualization
  • Comparative oncogenomics, where tumors from different organ sites converge on common genome structures as they progress toward metastasis

Services

PC-TRiADD’s Laboratory for Advanced Genome Analysis supports small and large-scale projects across Canada and internationally for the following applications:

Microarray

Platform

  • Agilent catalog and custom design microarray

Applications

  • As a Certified Service Provider, all Agilent microarray applications are supported; LAGA specializes in:
    • Gene, exons and non-coding expression
    • Array Comparative Genomic Hybridization with CGH probes for genome-wide DNA copy number variation and SNP probes for copy neutral aberrations

Next Generation Sequencing

Platforms

  • Life Technologies Ion Proton
    • up to 80M reads / run, 1x200bp SE
  • Illumina MiSeq
    • a selection of 1M, 4M, 15M or 25M reads / run, from 2x50bp to 2x300bp PE

Applications

  • Exome sequencing
  • Amplicon sequencing including 16S rRNA genes
  • Target capture sequencing
  • RNA sequencing (Quantitation)
  • RNA sequencing (Transcriptome)
  • Small RNA sequencing
  • Microbial and viral whole genome sequencing, including metagenomics

Bioinformatics

  • Acquisition, processing, statistical analysis, integration, and visualization of high-density genomic and transcriptome data from simple to complex experimental designs using one of several platforms
  • Utilization of software that allows seamless cross-platform integration and analysis of expression, genomic, and next generations sequence data making possible extremely powerful and comprehensive studies

News